Innovative approaches for personalised cardiovascular prevention
Principal Investigator: Stefania Boccia
Short title: INNOPREV
Announcement: National Project of Resilience Fund- PNRR: M6/C2_CALL 2022
Project Code: PNRR-MAD-2022-12375795
Start date: 01/05/2023
End date: 01/11/2025
Coordinator: Fondazione IRCCS Istituto Nazionale dei Tumori
Funding body: Ministero della Salute
Link: https://www.innoprev.it
Abstract: INNOPREV – Innovative Approaches for Personalized Cardiovascular Prevention represents an innovative response to the challenges posed by cardiovascular diseases (CVD), aiming to transform the approach to healthcare prevention. This multidisciplinary project brings together technology, genomics, and public health to implement tailored preventive strategies. The distinctive aspect of INNOPREV lies in its integration of data from different sources:
Genetics: The use of polygenic risk scores (PRS) makes it possible to estimate individual cardiovascular risk and tailor interventions accordingly.
Technology: Wearable devices and mobile apps collect real-time data, providing immediate feedback to users and researchers.
Lifestyle: The intervention goes beyond risk assessment, with a strong focus on behavioural change, promoting physical activity, healthy eating, and weight management.
Research
The core of the project is the clinical study, which involves 1,020 participants aged 40 to 69 living in the metropolitan areas of Catania, Palermo, and Rome. Participants, identified as being at high risk of developing CVD within the next 10 years, are divided into four intervention groups:
Traditional risk assessment.
Traditional assessment combined with apps and wearable devices.
Traditional assessment combined with PRS.
Combined assessment using apps, wearable devices, and PRS.
Methodology
Each participant completes a detailed questionnaire to gather information on:
Socioeconomic status
Lifestyle habits (smoking, alcohol, diet, physical activity)
Mental health indicators and overall well-being
The collected data will be used to calculate a personalised risk profile. The proposed interventions will vary depending on the participant’s group and will be monitored over a 24-month period.
Expected Outcomes
The study aims to assess:
The effect of the interventions on lifestyle changes
The modification of cardiovascular risk profiles
The impact of digital technologies on the healthcare system, using a Health Technology Assessment approach.